Aceclofenac 100 mg + Paracetamol 325 mg + Cetirizine 10 mg + Phenylephrine 5 mg + Caffeine 25 mg - Enfrio PlusEnfrio-Plus

How Enfrio-Plus works

This is a combination, and each component handles a different part of the problem. Cetirizine blocks the H1 histamine receptor. Histamine released from mast cells is what produces the sneezing, itching, watery eyes and runny nose of an allergic reaction, and this newer generation of antihistamine blocks it while barely entering the brain, so the drowsiness of the older agents is largely avoided. Phenylephrine narrows the swollen blood vessels in the lining of the nose. It is that swelling, not mucus alone, that blocks the nose during a cold, so shrinking the lining opens the airway and relieves the stuffiness and sinus pressure. Aceclofenac inhibits cyclo-oxygenase, the enzyme that makes prostaglandins. Prostaglandins are what sensitise nerve endings to pain and drive swelling and fever, so blocking them addresses inflammation itself rather than only the sensation of pain. Paracetamol reduces fever by acting on the temperature-regulating centre in the hypothalamus, which resets the body's thermostat back to normal, and raises the pain threshold centrally. It has very little effect on the stomach lining, which is why it is the first choice for fever and everyday pain in children and adults alike. Caffeine is included as an adjuvant. It constricts the dilated blood vessels that contribute to headache, and improves the pain relief obtained from paracetamol and aspirin, which is why the combination is used for headache rather than either component alone. Combining them means one preparation covers what would otherwise need two or three.